L-Histidine: Benefits, Deficiency Symptoms, and Its Role in Allergies – Health and Wellbeing News (2024)


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Histidine is called a semi-essential amino acid (protein building block) because adults generally produce adequate amounts but infants and children may not. Histidine is a precursor of histamine, a compound released by immune system cells during an allergic reaction.

Infants can obtain histidine from breast and formula milk, whilst pork, soybeans, cheese, baked beans, beef, kidney beans, turkey, dairy products, chicken, mung beans and chickpeas are good dietary sources of histidine.

What it does

  1. Anti-Arthritic: Levels of histidine have been shown to be depleted both in the blood serum and joint synovial fluid of rheumatoid arthritis (RA) sufferers, which suggests that histidine supplementation may be of benefit in RA. Some studies have shown benefits of histidine supplementation in strength and mobility in RA sufferers.
  2. Heavy Metal Protection: L-Histidine is needed along with L-cysteine to protect the body agains toxic metals such as mercury, lead, cadmium, and threatening excesses of essential minerals zinc and copper.
  3. Sexual Function: Histidine is needed to manufacture histamine, an essential compound for achieving sexual climax in both men and women. Men and women having difficulties achieving org*sms may be helped by histidine supplementation, as this may result in increased histamine levels in the sexual tract, which in turn may make org*sm and ejacul*tion easier. An additional pro-sexual effect of histidine may lay in its vasodilating effect, thus making blood flow to the sex organs easier.

Potential Uses

Circulatory disordersDetox of heavy metalsRheumatoid arthritis

What is L-histidine used for?

L-histidine is an essential amino acid, meaning that the body cannot produce it on its own and it must be obtained from food or supplements. L-histidine is used to produce histamine, a chemical messenger that helps to regulate a variety of bodily functions, including:

  • The immune system: Histamine helps to defend the body against allergens and infections.
  • Digestion: Histamine helps to stimulate the production of stomach acid and digestive enzymes.
  • Sleep: Histamine helps to regulate the sleep-wake cycle.

L-histidine is also used to produce carnosine, a compound that helps to protect muscles from fatigue.

Benefits of L-histidine

L-histidine may offer a number of health benefits, including:

  • Improved allergy symptoms: supplements may help to reduce the symptoms of allergies, such as sneezing, runny nose, and itchy eyes.
  • Reduced inflammation: has anti-inflammatory properties, which may be beneficial for people with inflammatory conditions such as arthritis and asthma.
  • Improved muscle function: helps to produce carnosine, a compound that helps to protect muscles from fatigue. This may be beneficial for athletes and people who exercise regularly.
  • Improved wound healing: is essential for wound healing. It helps to produce collagen, a protein that is necessary for the repair of damaged tissues.

L-histidine supplements

L-histidine supplements are available in capsule, powder, and liquid form. They are generally safe for most people to take, but it is important to talk to your doctor before taking any supplements, especially if you have any underlying health conditions.

The recommended dose of L-histidine supplements varies depending on the individual’s needs and goals. However, most people should not take more than 1 gram of L-histidine per day.

Histidine deficiency symptoms

Histidine deficiency is rare, but it can occur in people who do not consume enough protein or who have certain medical conditions, such as kidney disease or cancer. Symptoms of histidine deficiency can include:

  • Growth retardation
  • Muscle weakness
  • Fatigue
  • Anemia
  • Skin problems

Is histamine an amino acid?

No, histamine is not an amino acid. It is a chemical messenger that is produced from the amino acid L-histidine. Histamine is involved in a variety of bodily functions, including the immune system, digestion, and sleep.

L-histidine for allergies

Supplements may help to reduce the symptoms of allergies, such as sneezing, runny nose, and itchy eyes. This is because L-histidine helps to produce histamine, a chemical messenger that helps to regulate the immune system.

However, it is important to note that supplements can also increase histamine levels in the body. This can trigger allergic reactions in people who are already sensitive to histamine.

It is important to talk to your doctor before taking L-histidine supplements, especially if you have allergies.


Should be avoided by people with elevated levels of histidine or histamine such as those with manic depression, schizophrenia and chronic allergies.

Do not use in pregnancy or when breastfeeding.

As histamine triggers gastric secretions, histidine should not be taken by anyone with a peptic ulcer.

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L-Histidine: Benefits, Deficiency Symptoms, and Its Role in Allergies – Health and Wellbeing News (2024)


Does L-histidine help with allergies? ›

Because taking too much histidine can cause a copper deficiency, you may need to supplement your diet with extra copper. Although health practitioners use histidine less frequently than other amino acids, your body uses it to make histamine, which reduces your sensitivity to allergens.

What does L-histidine do to your body? ›

It's used in growth, repair of damaged tissues, and making blood cells. It helps protect nerve cells. It's used by the body to make histamine.

What are the symptoms of histidine deficiency? ›

Symptoms of low levels of histidine could include anemia (due to reduced hemoglobin production), slow wound healing, weakened immune system, and potential neurological issues like poor memory or cognitive function.

Who should not take histidine? ›

There isn't enough reliable information to know if histidine is safe to use in larger amounts as medicine when pregnant or breast-feeding. Stay on the safe side and stick to food amounts. Folic acid deficiency: People with folic acid deficiency should avoid histidine.

Does L-histidine raise histamine levels? ›

Supplemental histidine may have the potential to increase histamine production by gastric enterochromaffin cells and by mast cells. Indeed, one rat study has found that stomach levels of histamine are increased as histidine intake increases beyond normal dietary levels.

Can you take too much L-histidine? ›

At high intakes of histidine (>24 g/d), studies report adverse effects of histidine such as decreased serum zinc and cognitive impairment. There is limited research on the effects of histidine intake at doses between 4.5 and 24 g/d, and thus, a tolerable upper level has not been established.

What does histidine do to hair? ›

Histidine is an amino acid that absorbs excess copper from the hair. By removing the excess copper, it shields your hair more effectively from UVA and UVB rays that can cause your hair to become brittle and break off prematurely.

What does L-histidine do for skin? ›

Histidine is an amino acid that has antioxidant and soothing properties for skin. It is a key building block of the skin protein filaggrin, which plays a leading role in maintaining skin's barrier.

What foods are high in L-histidine? ›

L-histidine can be found in pork, beef, lamb, chicken, turkey, fish, soy, beans, milk, cheese, nuts, seeds, whole grains and eggs. A recent study showed that supplementing with 4g of L-histidine per day improved clinical signs and symptoms of atopic dermatitis by about 32%.

What happens if you don't get enough histidine? ›

The results of a study that recruited women with obesity and metabolic syndrome suggest that histidine supplements may lower BMI and insulin resistance. Deficiency can cause anemia, and low blood levels appear to be more common among people with arthritis and kidney disease.

What are the symptoms of histidinemia deficiency? ›

  • Behavioral Abnormality. Synonym: Behavioral Abnormality. Synonym: Behavioral Changes. ...
  • Hyperactivity. Synonym: Hyperactive Behavior. ...
  • Moderate Global Developmental Delay. Synonym: Global Developmental Delay, Moderate.
  • Neurological Speech Impairment. Synonym: Speech Disorder. ...
  • Specific Learning Disability.

Is histidine anti inflammatory? ›

Histidine is transported into cells by both neutral and basic amino acid transport pathways, and the histidine concentration is much higher in cells than in the plasma [15]. Histidine would therefore provide an anti-inflammatory effect within the cells.

What is the difference between histidine and L-histidine? ›

L-histidine is the L-enantiomer of the amino acid histidine. It has a role as a nutraceutical, a micronutrient, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a human metabolite, an algal metabolite and a mouse metabolite. It is a proteinogenic amino acid, a histidine and a L-alpha-amino acid.

What is a substitute for histidine? ›

Surprisingly, substitution of a neutral residue, alanine, for histidine at position 1106 resulted in an increase in binding to immune aggregates without subsequent reduction in the hemolytic activity.

What is L-histidine good for? ›

L-histidine (HIS) is an essential amino acid with unique roles in proton buffering, metal ion chelation, scavenging of reactive oxygen and nitrogen species, erythropoiesis, and the histaminergic system.

Which amino acid is an antihistamine? ›

Histidine is antagonistic to histamine and plays an important part in histamine-adrenalin balance in shock.

Does Dao help with allergies? ›

DAO keeps histamine levels in a healthy range to avoid uncomfortable histamine-induced symptoms. Diamine oxidase (DAO) is an enzyme that helps break down excess histamine in your body, thus easing uncomfortable symptoms, such as nasal congestion, itchy skin, headaches, and sneezing.


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